Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums
نویسندگان
چکیده
Key Laboratory of Bioorganic Chemistry a Education, Beijing National Laboratory for Chemistry and Molecular Engineering, Pe Academy for Advanced Interdisciplinary Stu China. E-mail: [email protected] Laboratory of Chemical Genomics, School Peking University Shenzhen Graduate Schoo † Electronic supplementary information ( and characterisation data for all comp 1433182 and 1433188. For ESI and cr electronic format see DOI: 10.1039/c6sc00 Cite this: Chem. Sci., 2016, 7, 5530
منابع مشابه
[Development of new synthetic methods and their application to synthesis of useful compounds].
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A bioinspired enantioselective synthesis of crinine-type alkaloids has been developed by iridium-catalyzed asymmetric hydrogenation of racemic cycloenones. The method features a biomimetic stereodivergent resolution of the substrates bearing a remote arylated quaternary stereocenter. Using this protocol, 24 crinine-type alkaloids and 8 analogues were synthesized in a concise and rapid way with ...
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تاریخ انتشار 2016